Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.

River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yu et al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.