Analysis of the p14 and p16 mutations in cutaneous melanoma

Introduction. Cutaneous melanoma is a malignant tumour derived from melanocytes that occurs primarily in the skin. It is a result of prolonged exposure to mutagenic factors and an abnormal DNA repair system. The pathogenesis of this tumour is complex and depends to a large extent on inactivation of the CDKN2A gene, whose protein products are involved in cell cycle control. The CDKN2A gene encodes two transcripts – p16 protein, which is an inhibitor of cyclin-dependent kinases (CDK4/CDK6), and p14ARF protein, responsible for stabilizaSŁOWA KLUCZOWE: czerniak, CDKN2A, p16, p14ARF, SSCP.