Synthesis of 9,11-Ethano-13,15-isoxazolinoprostanoids, PGH Analogs

The 1,3-dipolar addition to terminal alkenes of nitrile oxides generated from nitromethylene derivatives of bicycloheptane provided 9,11-ethano-13,15-isoxazolinoprostanoids with alkyl, phenyl, or additional heterocyclic fragment in the ω-chain.