P-MD013. Importance of bioactive flavonoids “pectolinarin” in inflammation and pain: Validation through in-vivo, in-vitro and molecular study

Introduction. Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury which further generates chronic inflammatory diseases such as rheumatoid arthritis, peripheral nerve disorders, asthma, cardiovascular diseases, diabetes, cancer etc. Flavonoids represent a huge family of polyphenolic compounds and more referred as “nutraceuticals” because of their vide range of pharmacological activities in the mammalian cell. Pectolinarin is one of the main phytoconstituents of Cirsium japonicum which is an important herb of Korea, China and Japan. Methods. Pharmacological data have been collected and analyzed for analgesic and anti- inflammatory activity through various in-vivo and in-silico model. Moreover molecular study was also performed through scientific data analysis to know their interaction with various inflammatory markers to confirm their pharmacological activity. Present work also summarized the scientific data analysis of various molecular studies of pectolinarin with inflammatory receptor targets such as COX-2, TNFα, IL-1β and IL-6. Results. Scientific data analysis showed that pectolinarin reduces tissue damage and alleviates the oxidative and inflammatory events through direct influence on COX-2, TNFα, IL-1β and IL-6. Molecular study against inflammatory receptor targets showed their effectiveness in the inflammatory disorders. Further data analysis also suggested that pectolinarin significantly inhibited cell viability in rheumatoid arthritis and have inhibitory activities against carrageenan-induced mouse paw edema and arachidonic acid-induced mouse ear edema in some other study. However pectolinarin also exert significant analgesic and anti-inflammatory activities in mice and rats which also support the molecular study. Owing to the importance of pectolinarin in the medicine, a better understanding of their biological activities indicates their potentials as anti-inflammatory agents. Conclusion. Present study data analysis indicated and proven the anti-inflammatory potential of pectolinarin which can be exploited for commercial designing of novel anti-inflammatory drug in the future to treat various inflammatory disorders.