Research progress on tumor-vessel associated extravascular tumor metastasis

The occurrence of malignant tumors is increasing annually around the world. In every year, 8.2 million patients died of malignant tumors in which about 90% patients died of malignant tumors associated multiple organs metastases. Inhibiting tumor metastasis is the key event to prolong the survi-val time of patients. With the further research, tumor-vessel associated extravascular tumor metastasis is playing an increasingly important role in the clinical application. This paper summarizes the new developments of tumor-vessel associated extravascular tumor metastasis to provide possible ideas for the therapy of malignant tumors. Key words: Malignancy; Extravascular metastasis; New developments