Expressions of p53 and p16 and their clinical significance in thyroid papillary carcinoma

Objective:To investigate the expressions of p53 and p16 in the papillary thyroid carcinoma(PTC)and their clinical significance.Methods:Immunohistochemistry was used to detect the expressions of p53 and p16 in 157 cases of PTC and 30 cases of thyroid tumor.Results:The expression of p53 in PTC was significantly higher than that in benign tumors(P0.005),and with the increase of the pathological grade of PTC,the expression of p53 increased significantly(P0.01),the expression of p53 in cases with neck lymph node metastasis was higher than that in cases without(P0.05),the expression of p16 in PTC was significantly lower than that in benign tumors(P0.005),and with the increase of the pathological grade of PTC,the expression of p16 was reduced significantly(P0.01),the expression of p16 in cases with neck lymph node metastasis was significantly different compared with that of cases without(P0.01).Conclusions:The mutation of gene p53 and the loss expression of gene p16 may promote the genesis,progress and metastasis of PTC;gene p16 may play an important role in the middle and advanced stages of PTC,which is of great clinical value and can be used as a reference index in judging the malignant degree of PTC.