Исследование кинетики щелочного гидролиза и NO-донорной активности химиотерапевтического препарата тенонитрозол

The kinetics of alkaline hydrolysis of N-(5-nitro-2-thiazolyl)-2-thiophenylcarboxanide (tenonitrozole) was studied by photometric and polarographic techniques, and the thermodynamic parameters in the intermediate state of this process were determined. A mechanism explaining the nitric oxide production during the hydrolytic decomposition of tenonitrozole is proposed. It is suggested that the antiprotosoal and antimicrobial activity of this drug under anaerobic conditions is related to the formation of nitro radical anions and NO. Under aerobic and microaerophilic conditions, the hydrolysis of tenonitrozole may lead to the formation of a peroxynitrate anion, which is a strong cytotoxic agent.