A phase I study of the combination of a DNA topoisomerase inhibitor, idarubicin, with the histone deacetylase inhibitor vorinostat, in advanced acute leukemia

Tapan M. Kadia,G. Borthakur,William G. Wierda,Farhad Ravandi,S. Faderl,Willie Newsome,James A. Zwiebel,Merrill J. Egorin,G. Garcia Manero

A phase I study of the combination of a DNA topoisomerase inhibitor, idarubicin, with the histone deacetylase inhibitor vorinostat, in advanced acute leukemia

2016

Tapan M. Kadia
G. Borthakur
William G. Wierda
Farhad Ravandi
S. Faderl
Willie Newsome
James A. Zwiebel
Merrill J. Egorin
G. Garcia Manero

7066 Background: Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor (HDACi) with single agent activity in patients with advanced leukemia. HDACi lead to the acety...

Keywords:

Vorinostat
Acute leukemia
Histone deacetylase inhibitor
Suberoylanilide Hydroxamic Acid
Cancer research
Pathology
Leukemia
Topoisomerase inhibitor
Idarubicin
Medicine
phase i study
single agent

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