Study of African Trypanosomiasis and Leishmaniasis. Volume 1. Summary.

Abstract : Investigators continued to monitor the antigenic stability of parasites from western Kenya. Current evidence indicates that there was a significant antigenic shift in the 1980-81 outbreak. Epidemiology and treatment record analysis studies continued. A treatment center was opened in western Kenya situated north of the Lambwe Valley endemic area and to the east of the Ugandan epidemic area. This center will serve as a routine treatment facility and research facility for the evaluation of standard drugs available and USMRDC developed drugs effective in screens against human African trypanosomiasis. An experimental compound WR 163577 is being evaluated in the goat model against T. brucei infection.