The preparation of benzoisothiazolo[1,2-b][1,2]isoquinolin-11-one-1,1-dioxides from dilithiated ortho-toluic acids and lithiated methyl 2-(aminosulfonyl)benzoate
2004
Select dilithiated ortho-toluic acids were prepared in excess lithium diisopropylamide and condensed with methyl 2-(aminosulfonyl)benzoate followed by a twofold cyclization of intermediates to afford benzoisothiazolo[1,2-b][1,2]isoquinolin-11-one-1,1-dioxides, a new fused-ring heterocyclic system.
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