Inhibitory Effect of 1,2-bis(2-Benzim-idazolyl) 1,2-ethanediol Derivatives on Poliovirus

THE inhibitory properties of 2-(α-hydroxybenzyl) benzimidazole (HBB) on the replication of poliovirus have been fully demonstrated1,2. O'Sullivan et al.3 also reported that 1,2-bis(2-benzimidazolyl) 1,2-ethanediol (I) has a selective inhibitory action on the multiplication of poliovirus. On the basis of these findings, we have synthesized, 1,2-bis(2-benzimidazolyl) 1,2-ethanediol derivatives and tested them for their anti-poliovirus effect.