IN VIVO INCORPORATION OF GLUCOSE CARBON INTO BRAIN AND LIVER PROTEINS IN BIOTIN-DEFICIENT RATS

: The in vivo utilization of D[U-14C]glucose with particular reference to its incorporation into brain and liver proteins was studied in biotin-deficient rats. The data show a significant reduction in the incorporation of glucose carbon into brain and liver proteins. A disturbance in the intermediary metabolism of glucose to be one of the factors responsible for the decreased incorporation of the label into proteins in biotin deficiency.