LC-MS/MS Analysis of MDMA in Ecstasy Tablets in Morocco

Ecstasy is a popular name designated for 3,4-methylenedioxymethamphetamine (MDMA). It displays effects related to amphetamine-type drugs and a set of distinctive effects like restlessness, well-being, and others effects. The aim of this work is to analyze ecstasy tablets seized in Morocco; studying their MDMA contents and their MDMA contents variations. We collected 12 batches of samples seized by Morocco Police that were analyzed by liquid chromatography coupled to tandem Mass Spectrometry to determine MDMA concentration presents in these tablets. The method was also validated in the following parameters: linearity, limits of detection and of quantification, precision and accuracy, to permit the MDMA quantification. A great variability among ecstasy tablets compositions was detected and the toxicological features were discussed.