PCR array analysis of gene expression profiles in chronic active Epstein–Barr virus infection

Abstract To determine the host cellular gene expression profiles in chronic active Epstein–Barr virus infection (CAEBV), peripheral blood samples were obtained from three patients with CAEBV and investigated using a PCR array analysis that focused on T-cell/B-cell activation. We identified six genes with expression levels that were tenfold higher in CAEBV patients compared with those in healthy controls. These results were verified by quantitative reverse transcription-PCR. We identified four highly upregulated genes, i.e ., IL-10 , IL-2 , IFNGR1 , and INHBA . These genes may be involved in inflammatory responses and cell proliferation, and they may contribute to the development and progression of CAEBV.