Could the seed of mamey sapote relieve the postoperative pain

Background: The pain management is a priority for human life as well as a public health problem. Currently, many patients suffer this disagreeable sensory, and then alternative analgesics are needed urgently. The purpose of this paper is to explore the potential use of the seed obtained from mamey sapote ( Pouteria sapota ) for antinociception in patients suffering postoperative pain. Materials and methods: The hypothesis suggests that the aqueous extract of the seed obtained from the mamey sapote could relieve the acute and chronic pain in patients after surgical procedures. The literature was reviewed and the antioxidant capacity of mamey seed was determined to support the hypothesis and the benefits for pain relief.  Results: The antinociceptive effect of mamey seed extract could be produced by their substantial content of antioxidants that might act against the effects of reactive oxygen and nitrogen species alongside the flavonoid-related activation of serotonin and opioid receptors, which have a crucial role for the development and progress of acute and chronic nociception.  Conclusions: This research provides the basis to establish an innovative, viable, and alternative therapy using the mamey seed for pain relief in patients experiencing postoperative nociception.