The response of microglia in the diabetic retinopathy—To explore changes of microglia from the view of neurovascular unit

Being one of the most serious microvascular complications of diabetes,diabetic retinopathy(DR) is the leading cause of new cases of blindness among adults.Though the pathogenesis of DR still remains to be completely elucidated,increasing evidences suggest that microglial cells play an important role in the occurrence and development of DR.This review expect to summary the changes of distribution,morphology,surface marker profile and function of microglial under physiological condition and diabetic background,and to further explore the physiological conditions of neurovascular unit in the function and regulation of microglial and its possible mechanism involved in DR. Key words: microglia;  diabetic retinopathy