Design, Synthesis, and Biological Evaluation of Thieno[2,3‐c]pyrazole Hydrazide Derivatives as Potential Antimicrobial Agents

In search of new antimicrobial agents with enhanced potency, we have designed and synthesized three series of hydrazones with 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbohydrazide. All the synthesized compounds have been screened for their in vitro antibacterial and antifungal activities by employing broth microdilution method. It is observed that compounds are more susceptible to Vibrio cholerae than other tested strains. In particular, compounds (3a), (3c), (5g), and (5 h) are highly potent against bacterial strain V. cholerae. The results suggest that hydrazones bearing two core pyrazole scaffolds would be potent antimicrobial agents.