Extended-spectrum-lactamases and the antibiotic resistance in uropathogeni escherichia coli in children

Objective To investigate the prevalence of extended-spectrum -lactamases（ESBLs） and the antibiotic resistance in uropathogeni escherichia coli in children. Methods A total of 48 uropathogenic escherichia eoli strains isola- ted, ESBLs-producers were detected by CLSI phenotypic confirmatory test and susceptibilities were tested by agar dilution method. Results 45.8% of isolates were ESBLs producers in those isolates, and ESBLs-producers account for 66.7% strains in the complicated urinary tract infection. ESBLs producers were highly resistant to ampicillin, cefazolin, cefuroxime and cefotaxime. The resistant rate of ceflazidime, cefepime, amoxicillin-clavulanic acid was more than 30%, cefoperazone- sulbactam, cefmetazole and aimikacin was less than 30% , none was resistant to meropenem in ESBLs producers. The re- sistant rate of ampicillin, cefazolin, cefuroxime was more than 40% and most were susceptible to other antimicrobial agents in non ESBLs producers. The resistant rate of cefazolin, cefuroxime, cefotaxime, ceftazidime and cefepime was significantly higher in ESBLs producers than that in non ESBLs producers. Conclusions With resistance to most of antimicrobial a- gents, ESBLs-producers are highly prevalent in uropathogeni escherichia coli isolates in children, so more attention should be paid to survey and detect those strains. Key words: Children ;  Urinary tract infection ;  Escherichia coli ;  Extended-spectrum -lactamases ;  Resistance