Studies on Antischistosomal Drugs. XXIII. Drug Effects on Alimentary Absorption of Sb and the Promoting Effects of BAL-GIucoside.

(1)By comparing the Sb content remained in the alimentary tract(including feces)of mice 6 hours after intragastric administration of tartar emetic 27 mg/kg,we have studied the influences on thealimentary absorption of tartar emetic by 34 drugs consisting of surfactants,lubricants, drugs acting on nervous system,vitamins,polyalcohols,organic acids,thiols,glucose and its deriva- tives,etc.Only BAL-glucoside was found to be able to promote the Sb absorption. (2)In mice fed tartar emetic 27 mg/kg,the alimentary Sb content was 29％ lower in the group with simultaneous administration of BAL-glucoside 0.21g/kg than that in the group without BAL-glucoside.When the dosage of BAL-glucoside was increased to 2.5 g/kg,the alimentary Sb content became 60％ lower. Mice were fed tartar emetic 55 mg/kg or fed 25 mg/kg plus BAL-glucoside 194 mg/kg daily for 14 days.The visceral Sb amounted to 128ug/g dry weight in the former group,and 188ug/g in the latter. Rabbits infected with Schistosoma japonicum were fed tartar emetic with BAL-glucoside(0.21 g/kg).After 24 hours,the liver Sb and the worm Sb contents were 3—4 times those in the group without BAL-glucoside. (3)The effect of BAL-glucoside was not due to the change of pH in the alimentary tract,nor simply due to the presence of SH group or glucose alone.It is surmised that,during the absorption of the glucoside residue of BAL-glucoside,the Sh was meantime conveyed in by the SH group. (4)BAL-glucoside enhanced the toxicity and decreased the therapeutic value of tartar emetic. (5)Though BAL-glucoside did not satisfy our demand,it offered a precious clue as to solve the mechanism of Sb absorption and to search for ideal agents promoting the absorption of Sb.