Kidney Function in Acromegaly
2009
Creatinine clearance and daily urinary albumin and β2-microglobulin excretion rates (radio-immunoassays) were measured several times in 14 patients with acromegaly. Eleven patients were treated with bromocriptine, 5 to 55 mg/day. The activity of the disease was assessed by measuring urinary growth hormone excretion (radio-immunoassay).
In agreement with previous investigations we found the creatinine clearance elevated. However, no correlation was found between this variable and the urinary growth hormone excretion. Urinary albumin and β2-microglobulin excretion rates were not significantly different from our previous results in 27 adults control subjects. There was no correlation between urinary growth hormone excretion and urinary albumin or β2-microglobulin excretion rates. Bromocriptine treatment reduced urinary growth hormone excretion from 220 to 91 ng/24 hours, p<0.01, but no significant alterations were induced in the above mentioned kidney function variables.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
12
References
10
Citations
NaN
KQI