Effects of Lung Recruitment Maneuvers in Patients with Acute Respiration Distress Syndrome

Objective To investigate the clinical effects and safety of recruitment maneuvers(RM) combined with lung protective strategy in patients with acute respiratory distress syndrome(ARDS).Methods Sixteen ventilated patients with ARDS underwent RM using a pressure of 40 cmH2O for 40s,without any neuromuscular blocking agents.Results After RM treatment,both arterial oxygen saturation(SaO2)and partial pressure of arterial oxygen(PaO2) were significantly increased in 10 min、30 min、1 hr and 2 hr(P0.05).There was no significant difference in the partial pressure of carbon dioxide(PaCO2)before and after RM(P0.05).The peak inspiratory pressures(PIP),heart rate(HR) and plateau inspiratory pressures(Pplat) had no significant difference between after and before RM(P0.05),but respiratory system compliance(Crs) increased markedly after RM(P0.05).The central vein pressure(CVP) and mean arterial pressure(MAP) increased during recruitment(P0.05),but there was no significant difference after RM(P0.05).Conclusion RM can improve oxygenation,Crs and PaO2/ FiO2 of the patients with ARDS.This study also suggests that RM is safe for hemodynamics.