The characteristics of duodenogastric reflux in peptic ulcer and chronic gastritis

Patients with gastroduodenal ulcer, chronic gastritis (CG) and healthy controls (124, 57 and 24 subjects, respectively) were examined for intensity and duration of duodenogastric reflux (DGR). These indices were assessed by concentrations of gastric juice bilirubin. It is found that DGR occurred in 29% of the examinees free of gastroduodenal diseases, does not correlate with morphological CG-induced changes and Helicobacter pylori contamination degree. The reflux in CG seems to be secondary in pathogenesis of this disease. In patients with aggravated duodenal and gastric ulcer the reflux in the basal stage is 2-2.5 and 5-6 times higher than in the controls, respectively. DGR parameters correlated with the height of the ulcer defect. Retrograde entrance of the duodenal content into the stomach in duodenal ulcer enhances acid production in the stomach through gastrin mechanisms.