Susceptibility of Xeroderma pigmentosum cells to transformation with oncogenes

Abstract Oncogenes capable of transforming 3T3-Vill cells were not detected in ‘normal’ Xeroderma pigmentosum (XP) fibroblasts but were detected in two out of six XP epitheliomas. Preliminary results concerning the transfection of ‘normal’ XP fibroblasts with activated ras genes seem to indicate that these cells are as resistant as the healthy controls to the transforming action of the group II oncogenes. However, after transfection with v- myb oncogene in XP fibroblasts several cellular clones have been isolated showing some new phenotypic characteristics.