Experimental Human Pneumococcal Colonisation in Older Adults is Feasible and Safe, Not Immunogenic

Hugh Adler,Esther L. German,Elena Mitsi,Elissavet Nikolaou,Sherin Pojar,Caz Hales,Rachel Robinson,Victoria Connor,Helen Hill,Angela D Hyder-Wright,Lepa Lazarova,Catherine Lowe,Emma L. Smith,India Wheeler,Seher Zaidi,Simon P. Jochems,Dessi Loukov,Jesús Reiné,Carla Solorzano-Gonzalez,Polly De Gorguette DArgoeuves,Tessa Jones,David Goldblatt,Tao Chen,Stephen Aston,Neil French,Andrea M. Collins,Stephen B. Gordon,Daniela M. Ferreira,Jamie Rylance

Experimental Human Pneumococcal Colonisation in Older Adults is Feasible and Safe, Not Immunogenic

2020

Rationale: Pneumococcal colonisation is key to the pathogenesis of invasive disease, but is also immunogenic in young adults, protecting against re-colonisation. Colonisation is rarely detected in ...

Keywords:

Streptococcus pneumoniae
Young adult
Colonisation
Antibody
Pathogenesis
invasive disease
Immunology
Medicine

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