[Calcium-permeable cation channel activated by growth factors].

: Calcium is required for cell-cycle progression. Growth factors which promote G(1) progression activate calcium-permeable cation channels and induce sustained increase in calcium entry. Inhibition of these channels blocks the action of growth factors. Despite of the physiological significance, little is known about the molecular nature of the growth factor-regulated channels. Recently, primary structure of GRC-1, one of growth factor-regulated channel, was identified.