ANTIDIABETIC ACTIVITY OF AERIAL PARTS OF ARGEMONE MEXICANA LINN. IN ALLOXAN INDUCED HYPERGLYCAEMIC RATS
2011
Summary Argemone mexicana L. (Papaveraceae), commonly known as prickly poppy, is an indigenous herb used as a medicinal plant in several countries. The present study was designed to investigate the possible actions of ethanolic and aqueous extract of aerial parts of Argemone mexicana Linn , on glucose homeostasis in acute normoglycemic and alloxan induced hyperglycemic rats, including oral glucose tolerance and up to 11-days of study in hyperglycaemic rats. The body weight measurement and certain serum biochemical estimation were undertaken in 11-days treated hyperglycemic rats. Both extracts were used at dose levels of 200 and 400 mg/kg each by oral route, keeping glibenclamide (5 mg/kg) as standard drug. The biochemical parameters used in the study are blood glucose concentration, urea, creatinine, triglyceride, cholesterol. The test result revealed that in normoglycemic rats
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