Effects of Different Amounts of Ethyl Alcohol Intake on Cardiac Structure,Function and Oxidative Stress

Objective:To explore the effects of different amounts of ethyl alcohol intake on cardiac structure and function,and the effects of oxidative stress on cardiac muscle injury caused by ethyl alcohol.Methods:Two hundred and ninety-three subjects were divided into 4 groups according to the different amounts of ethyl alcohol intake including small amounts of alcohol group(5-20 g/d),the median amounts of alcohol group(20-80 g/d),large amounts of alcohol group(≥80 g) and non-alcohol group(5 g/d).The echocardiogram test was performed in subjects.The levels of blood B urine sodium peptide(BNP),superoxide dismutase(SOD)and metal sulfur protein(MT) were also detected.Results:The left ventricular end systolic diameter(LVSD),the left ventricular end diastolic diameter(LVDD) and the level of serum BNP increased,but the left ventricular ejection fraction(LVEF),the left ventricular fractional shortening(FS) and E/A ratio decreased in median and large amounts of alcohol groups than those of non-alcohol group.The values of LVSD and LVDD increased,but LVSD and LVDD decreased in large amounts of alcohol group than those of median amounts of alcohol group.There was a higher serum level of MDA in median and large amounts of alcohol groups compared with that of non-alcohol group and small amounts of alcohol group.There were significantly lower serum levels of SOD and MT in median and large amounts of alcohol groups than those in small amounts of alcohol group and non-alcohol group(P 0.05).Conclusion:Median and large amounts of alcohol intake induced cardiac dilatation and heart dysfunction.There was no influence on cardiac structure and function with small amounts of alcohol intake.The large and median amounts of alcohol intake activate oxidation stress,while small amounts of alcohol intake reduce the level of oxidation stress.