Early use of immunoglobulin in septic shock

In addition to the interventions suggested by the guidelines of the Surviving Sepsis Campaign, in the recent years other therapeutic options have been proposed and tested for patients with severe sepsis and septic shock. Polyclonal intravenous immunoglobulins seem to be an interesting and useful option because of its activity in neutralizing endotoxin and in modulating the host immune response. In this retrospective study we assessed the effects of the early use of polyclonal intravenous immunoglobulins enriched with IgA-M (IgGAM) in addition to standard therapies on clinical outcome of patients with septic shock.