Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

Gregory H. Bird,Emanuele Mazzola,Kwadwo Opoku-Nsiah,Margaret Lammert,Marina Godes,Donna Neuberg,Loren D. Walensky

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

2016

Gregory H. Bird
Emanuele Mazzola
Kwadwo Opoku-Nsiah
Margaret Lammert
Marina Godes
Donna Neuberg
Loren D. Walensky

Detailed biophysical, microscopy, and statistical analyses of hydrocarbon-stapled peptide variants revealed how a combination of critical parameters such as hydrophobicity, α-helicity and isoelectric point influence cellular permeability.

Keywords:

Molecular biology
Biochemistry
Hydrocarbon
Helix
Biophysical chemistry
Isoelectric point
Chemistry
Peptide
Permeability (electromagnetism)
Drug delivery
stapled peptide
Biophysics

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