L-serine lowers the inflammatory responses during Pasteurella multocida infection

Pasteurella multocida causes a variety of infectious diseases in various species of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of host-pathogen interactions is unclear. Here we found that L-serine levels were significantly decreased in murine lungs infected with P. multocida. Exogenous L-serine supplementation significantly increased the survival rate of mice, and decreased the colonization of P. multocida in the lungs of mice. Notably, L-serine decreased the macrophage- and neutrophil-mediated inflammatory responses in mice during P. multocida infection.