Pharmacokinetics of Quinupristin/Dalfopristin in Patients with Severe Chronic Renal Insufficiency

Objective To compare the pharmacokinetic profile of a single intravenous injection of quinupristin/dalfopristin, a new injectable streptogramin, in healthy young individuals and patients with severe chronic renal insufficiency. A secondary objective was to assess the relative tolerability of this dose in these patients compared with healthy individuals.