AB0319 HEALTH-RELATED QUALITY OF LIFE ASSESSED BY LUPUSQOL IN 1102 LUPUS PATIENTS FROM RUSSIAN FEDERATION (RF), KIRGHIZSTAN AND KAZAKHSTAN (RENAISSANCE COHORT)

Background: Health related quality of life (HRQoL) is an aspect that is generally underexplored in the routine clinical practice but it is attracting more and more attention. Lack of concordance between physician derived outcomes of disease activity and patient HRQoL outcomes is commonly found in SLE. This is due to the fact that the former is influenced by the immunologic pathogenic inflammatory mechanisms while the latter may be affected by a variety of psychological, social and co-morbid conditions. Objectives: The aim of this study was to compare health-related quality of life assessed by LupusQoL in 1102 Lupus patients (pts) from the Russian Federation, Kirghizstan and Kazakhstan (RENAISSANCE cohort). Methods: 1102 SLE pts who fulfilled SLICC 2012 criteria were enrolled into the study. The SLEDAI 2K index activity, SLICC damage index, and HRQoL using the LupusQoL questionnaire (validated for the Russian-speaking population in 2018) were evaluated. Descriptive statistics, Spearman’s correlation coefficients were performed to analyze the data. Results: 400/600/102 Lupus pts from RF, Kirghizstan and Kazakhstan respectively were studied. The pts were predominantly female (91%/93%/98%) and of indigenous nationality (Russian 83%/ Kirghiz 88%/ Kazakh 76%) with a mean±SD age of 34,2±11,5/35,07±12,2/33,8±10,5 years (p=0,36; p=0,96) respectively. The mean disease duration (Мe) in RF/ Kazakhstan was 6 [3;12]/ 5[2;9] years (p=0,15), in Kirgizstan - 2[0,6; 7] years(p≤0,05). Kazakh pts (p=0,00) have higher disease activity (SLEDAI 2K) 17,6±8,8 than Kirghiz pts 15,1±8,3 and Russian pts 9,4±8,1. SLICC damage index 2,39±1,61 in Kazakh pts (p=0,00) was higher than in Russian 1,57±1,54 and Kirghiz 0,79±0,32 pts. 54% pts from RF and 58 % from Kazakhstan had high education. Only 33% pts from Kirgizstan also had high education. 45%/24%/33% pts from RF, Kirgizstan and Kazakhstan respectively had steady employment, 53%/30%/32% pts received disability benefits. HRQoL assessed by LupusQoL was low in all patients with SLE. The mean scores for each of the domains of LupusQoL are shown in Table 1. The statistically significant lowest HRQoL in all 8 domains is obtained among Kirghiz patients in the comparative analysis of HRQoL in SLE patients of RF and Kazakhstan. The HRQoL was comparable in lupus patients from RF and Kazakhstan. There was a strong correlation between Sum LupusQoL domain and age (r = -0.19), steady employment (r=0,28), high education (r = 0.19), disease duration (r = -0.29), SLEDAI 2K index activity (r = -0.22), SLICC damage index (r = -0.25). Conclusion: HRQoL assessed by LupusQoL was low in SLE pts from the RF, Kirgizstan and Kazakhstan. The lowest HRQoL is reported among Kirghiz patients in the comparative analysis of HRQoL with SLE patients in RF and Kazakhstan. The low HRQoL is associated with age, unavailability of work, low education, disease duration, disease activity and damage. Disclosure of Interests: None declared