Treatment of Superficial Papillary Transitional Cell Carcinoma of the Ureter by Vesicoureteral Reflux of Mitomycin C

AbstractWe report 2 cases of recurrent superficial papillary transitional cell carcinoma of the bladder with right vesicoureteral reflux in which superficial papillary transitional cell carcinoma developed in the distal ureter with reflux. Both patients received intravesical mitomycin C that was delivered by the vesicoureteral reflux to the tumor sites. Diagnosis and management were facilitated through the use of ureteroscopy, which allowed for accurate pathological staging and surveillance. No systemic toxicity or change in renal function was noted in either patient and both have remained free of recurrent tumor for more than 2 years.