Monitoring oxidative stress by novel clinically aplicable screening asssays in cardiac patients treated by primary percutaneous coronary angioplasty

The goal of emergency coronary unit procedures is to provide and normalize the oxygen blood supply to a heart as early as possible and without additional stress, so we use advanced method of percutaneous transluminal coronary angioplasty (PTCA). However, oxidative stress in the patients with myocardial infarction treated with PTCA was not analyzed yet. For this purpose following assays produced by companies Tatzber K.E.G and EliTec GmbH (Austria) were used: total serum peroxide levels (POX), serum peroxidase and peroxidase-like activity (A-R-S), total capacity of antioxidants (TCA) and antibody titer against oxidized LDL (oLAb). Preliminary results of trial that involved 29 patients monitored for seven days lead to following conclusions. Convalescence was associated with an increase of serum peroxide levels and of serum peroxidase and peroxidase- like activity. In spite of individual variations determined both during acute phase of illness and during convalescence, since there was no major changes of TCA and oLAb values, we assume that steady state of serum peroxide levels and peroxidase activities is important to achieve convalescence in cardiac patients treated with PTCA.