Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population

The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population. This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay. We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P = .015 and .009, respectively). Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.