Receptor modulators vitamin d.

A compound or a pharmaceutically acceptable salt thereof represented by Formula (I): ** (See formula) ** wherein R and R 'are independently C1-C5, C1-C5 haloalkyl, or together R and R '' ci-cloalquilo form a substituted or unsubstituted, saturated or unsaturated ring having from 3 to 8 carbon atoms ring; RP3 and RN are independently selected from hydrogen, halo, C1-C5, C1-C5 haloalkyl, -O-C1-C5 alkyl, -S-C1-C5 alkyl, -O-C1-C5 haloalkyl, -CN, -NO2 acetyl, -S-C1-C5, C2-C5 alkenyl, C3-C5 cycloalkenyl and C3-C5; RP is selected from: hydrogen, halo, C1-C5 alkyl, C1-C5, -O-C1-C5 alkyl, -S-C1-C5 alkyl, -O-C1-C5 haloalkyl, -CN, -NO2, acetyl , -S-C1-C5, C2-C5, C3-C5 cycloalkenyl and C3-C5; (LP1), (LP2), and (LNP) are divalent linking groups independently selected from: a bond, - (CH2) m-CH (OH) -, - (CH2) mO-, - (CH2) ms-, - (CH2) mS (O) -, - (CH2) mS (O) 2, - (CH2) mN (R40) -, - (CH2) mC (R40) (R41) -, - (CH2) m C (O ) -, -N (R40) -C (O) -, - (CH2) m-CH = CH-, and - (CH2) mC C-; where m is 0-5; R40 and R41 each independently selected from hydrogen, C1-C5, C1-C5 hydroxyalkyl, ha-loalquilo C1-C5, C2-C5, C3-C5, C3-C5 cycloalkenyl; ZP is selected from: alkyl branched C3-C5, C3-C10 hydroxyalkyl, C3-C10 hydroxyalkenyl, C3-C10 hydroxyalkynyl, C3-C10 hydroxycycloalkyl, C4-C10 hidroxicicloalquenilo, and oxocycloalkyl; ZNP is selected from: C1-C5 alkyl, C2-C5, C3-C5, cycloalkenyl C3-C5 hydroxyalkyl, C1-C5, C1-C5 alkyl C1-C5 hydroxyalkyl-C1-C5, C0-C5 - CO2H, C0-C3 alkyl-cycloalkyl-CO2H, C0-C5 alkyl-N (R40) (R41), -X- (C1-C5), -X- (C1-C5 alkenyl), -X- (C3 -C 5), -X- (nile cicloalque-C3-C5), -X- (C1-C5), -X- (C1-C5 hydroxyalkyl), -X- (C1-C5 alkylaryl), -X (O C1-C5) -Xn (R40) (R41), -xn (R40) aryl, -N (CH3) (OCH3), -N (OH) (CH3), -N (R42) - (C1- C5) CO2H, -N (R42) - (C1-C5) C (O) (C1-C5), -N (R42) - (C1-C5) C (O) (C1-C5) , -N (R42) -SO2- (C1-C5), -NR (42) -S (O) - (C1-C5), -P (O) - (O C1-C5 alkyl) 2, heteroaryl and -N = C (R40) N (R40) (R41); R42 is selected from: H, C1-C3 alkyl, and C1-C3 haloalkyl; and X is selected from: O, C (O), C (S), S (O), and SO2; with the proviso that - (LNP) -ZNP is substituted at the 12 or 13 position of the naphthalene ring.