Comparison between computational and experimental methods for the characterization of therapeutic ultrasound fields

Analytical modeling of medical ultrasound fields has been developed by the FDA to aid in pre-clinical characterization of therapeutic ultrasound devices. In order to assess this publicly available software, called the HIFU Simulator, acoustic and thermal measurements of power, pressure/intensity and temperature distribution have been performed for comparison. Measurement and modeling issues include using hydrophones and radiation force balances at therapeutic power levels, validation of simulation models, and tissue-mimicking material (TMM) development for temperature measurements. To better understand these issues, a comparison study was undertaken between simulations and measurements of the HITU acoustic field distribution in water and TMM, and temperature rise in TMM. For the specific conditions of this study, the following results were obtained. In water, the simulated values for p + and p- were 3% lower and 10% higher, respectively, than those measured by hydrophone. In TMM, the simulated values for ...