Astroglial and Microglial Activation in Hippocampus of Rat After Global Forebrain Ischemia

The astroglial and microglial reaction to ischemic neuronal death was studied in hippocampus of rats submitted to 30-min, near-complete forebrain ischemia. The global metabolic response to ischemia was assessed by measuring energy metabolism and protein synthesis, and the cell-specific reactions by using a battery of histological, in situ hybridization and immunocytochemical techniques.