Synergism Between Sequential Immunotherapy and Radiotherapy in A Malignant Pleural Mesothelioma Patient
2020
Malignant Pleural Mesothelioma (MPM) is a highly invasive tumor
that is linked to previous asbestos exposure. Combined multimodality
treatment, i.e induction chemotherapy followed by surgery, is
standard of care in highly selected patients. Platinum-doublet
chemotherapy is the first choice for inoperable or advanced disease.
There are no good recommendations for second-line treatment due
to the lack of a clear survival benefit. Chest wall invasion is common
and radiotherapy is used for pain control. We report the case of
an MPM patient that showed a remarkable response through
the combination of radiotherapy and immunotherapy. This case
illustrates that despite failure of single-agent checkpoint inhibition,
the combination of radiotherapy and immunotherapy has the
potential to overcome checkpoint-inhibitor resistance in MPM.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI