SYNTHESIS AND DNA BINDING PROPERTIES OF AMIDE BOND-MODIFIED ANALOGUES RELATED TO DISTAMYCIN

Yasuo Yamamoto,Tetsutaro Kimachi,Yoshitomo Kanaoka,Satoshi Kato,Kiyoshi Bessho,Takuyuki Matsumoto,Tetsuya Kusakabe,Yukio Sugiura

SYNTHESIS AND DNA BINDING PROPERTIES OF AMIDE BOND-MODIFIED ANALOGUES RELATED TO DISTAMYCIN

1996

Yasuo Yamamoto
Tetsutaro Kimachi
Yoshitomo Kanaoka
Satoshi Kato
Kiyoshi Bessho
Takuyuki Matsumoto
Tetsuya Kusakabe
Yukio Sugiura

Abstract Novel nitro analogues of distamycin which have trans olefin or α-diketo moiety instead of amide bond were synthesized. Their DNA binding properties studied by ethidium displacement assay and MPE footprinting experiments were also described.

Keywords:

Olefin fiber
Moiety
DNA
Stereochemistry
Footprinting
Nitro
Peptide bond
Distamycin
Organic chemistry
Chemistry
binding properties

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