Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines? B. LumbrerasS. GarteK. OvervadA. TjonnelandF. Clavel-ChapelonJ. P. Linseisen • H. BoeingA. TrichopoulouD. PalliM. PelusoV. KroghR. TuminoS. Panico •

Background The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require hostmediated metabolic activation before inducing DNA mutations. The role of SVLT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. Methods Data were collected as part of a case-control study nested within the EPIC cohort, the Gen Air