One-pot synthesis of AuPd@FexOy nanoagent with the activable Fe species for enhanced Chemodynamic-photothermal synergetic therapy.

Abstract Facile fabrication of Fe-based nanotheranostic agents with the enhanced Chemodynamic therapy (CDT) effect and multiple functions is important for oncotherapy. In this report, noble-metal@FexOy core-shell nanoparticles (Au@FexOy NPs, AuRu@FexOy NPs, AuPt@FexOy NPs and AuPd@FexOy NPs) are one-pot constructed by a simply redox self-assembly strategy. As a typical example, AuPd@FexOy NPs are applied for oncotherapy. Compared to their crystalline counterparts (e.g., AuPd@c-Fe2O3 nanocrystals (NCs)), AuPd@FexOy NPs with the metastable FexOy shell can be activated by a small amount of NaBH4 to obviously enhance the production of ·OH in subsequent Fenton reaction (these activated products are termed as r-AuPd@Fe xOy NPs). In addition, a favorable photothermal effect (63.5% photothermal conversion efficiency) of r-AuPd@FexOy NPs can further promote the ·OH generation. Moreover, r-AuPd@FexOy NPs also show a pH-responsive T1 -weighted MRI contrast property, CT imaging capacity and the function of regulating tumor microenvironment. This work presents an attractive route to prepare versatile nanotheranostic agents.