Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin
2019
Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N′-dimethylethylenediamine. These structural analogs of prodimin, a water insoluble anticancer drug, are soluble in water, which significantly expands methods for their administration into a body. The compounds obtained and prodimin (as a reference substance) were studied on P388 murine leukemia and some of its drug-resistant strains. The data obtained suggest a high efficacy of one synthesized compound against drug-resistant tumors.
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