Effect of atorvastatin on carotid intima-medial of thickness of primary hypertension patients of Han nationality in China

Objectives To investigate the efficacy of 10 mg or 20 mg atorvastatin + long acting antihypertensive in carotid imtima-medialthickness(IMT).Methods 151 patients of Hart nationality in South China with mild hypertensive were randomly divided into 3 groups:atorvastation 10 mg group(n = 50) recevie 10 mg atorvastation and amlodipine + benazepril;atorvastation 20 mg group(n = 61)receive 20 mg atorvastation and amlodipine + benazepril;the control group(n = 40)recevie amlodipine + benazepril.The patients were detected IMT,vascular function,lipids and inflammatory factor in pretherapy and every 3 months.Results atorvastatin 10 mg or 20 mg groups have significantly change contrast to coutrol group:(1) IMT was decreased(P 0.01).(2)Adia-P% and Adia-N% were increased(P 0.01).(3)LDL-C level was decreased by 30% in a atorvastatin 10 mg group and 40.48% in 20 mg group respectively(P 0.01). Conclusion Atorvastatin delays the development of artherosclerosis in hypertensive patients,improves endothelial function,and strengthens the effect of lipid-lowering.