Diver CE aspiration increases artery flow in acute ST-elevation myocardial infarction following primary percutaneous coronary intervention

Objective To examine whether Diver DE aspiration increasing hish TIMI thrombus grade artery flow in acute ST-elevation myocardial infarction (ASTEMI) undergoing primary PCI.Methods All patients were grouped by the thrombus grades into two groups:high thrombus load group and low thrombus load group,and the patients in the above two groups were further randomly assigned,according whether need aspiration,to aspiration group and no aspiration group.TIMI,adjusted TIMI numbers of frames,resolution of maximal ST-segment elevation,and LVEF were calculated in 5-7 days after operation;Major adverse cardiovascular events(MACE) were tracked during hospitalization and in one month following-up.Results The length of target lesions is longer,the numbers ofbracket is more,in the high thrombosis load group ((36.4±15.1)mm,45) than the low load group ((31.4±13.7)mm,30) (t=-2.16,χ~2=5.9921,P<0.05).TIMI blood flow above grade 3(χ~2=5.3299,P<0.05),myocardialvisualization greater than grade 3(χ~2=6.9509,P<0.05),and ST segment resolution greater than 50%(χ~2=9.7082,P<0.05) is different between aspiration group and non-aspiration group in these with high thrombosis loads.But apart from the ST resolution(χ~2=4.6590,P<0.05),the other indexes were not significantly different in the low thrombosis load group.LVEF is higher in aspiration group than in non-aspiration group,in the high thrombosis load group((58.7±7.8)% vs.(52.3±8.9)%)(t=3.23,P<0.05) and in low thrombosis load group((59.1±7.6)% vs.(55.1 ±9.8)%)(t=2.07,P<0.05).It was found that a significant decrease of MACE rate in total aspiration group compared with no aspiration group(χ~2=4.0332,P=0.0446),and there was only a lower trend in high thrombus level between two groups(χ~2=3.5625,P=0.0591).Conclusiom Diver CE aspiration,increasing infarction related artery flow,would improve the prognosis of ASTEMI following primary percutaneous coronary intervention. Key words: Myocardial infarction; Pereutaneous coronary intervention; Thrombus aspiration; Thrombus load