POPULATION PHARMACOKINETICS OF 5-FLOURO URACIL IN INDIAN CANCER PATIENT POPULATION

The aim of the present study was to describe the population pharmacokinetics of 5-flourouracil in Indian cancer patient population. The covariates evaluated were total body weight, height, age, dose and gender. A total of 85 steady state serum concentrations were collected from 44 patients and analyzed. 5-FU pharmacokinetics is followed by one compartment first order elimination. Additive model is best described the pattern of residual error using both FO and FOCE method. NONMEM was performed to investigate the effect of patient covariates on pharmacokinetics and to investigate the relative magnitude of inter individual variability. No covariate is influencing the CL and VD of 5-FU.The final model estimates of CL/F and V/F estimated by FO method were 74.5/h and 11.8 L respectively and by FOCE method are 72.3 L/h and 12 L respectively.