Role of AMPK and its possible interactions in metformin therapy and physical exercise - Research perspectives -

Hyperglycemia is a consequence of glucose resistance by the insulin hormone, insufficiency found in people suffering from type 2 diabetes. Studies demonstrate expressive and beneficial results of physical exercise associated with metformin in response to the activation of a protein called AMPK, which stimulates The translocation of Glut4 a glucose transporter by which improves the picture of glucose sensitivity by decreasing hyperglycemia. The present review seeks a greater understanding on the effects of physical exercise and Metformin on the AMPK enzyme in the metabolism of glucose in diabetic people.