Association between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7,697 Cases and 13,125 Controls Running title: Mamasoula: MTHFR C677T polymorphism and congenital heart disease

Research, Eunice Kennedy Shriver National Inst of Child Health & Human Development, National Institutes of Health, Dept of Health & Human Services, Bethesda, MD; Congenital Malformations Registry, New York State Dept of Health, Troy & Dept of Epidemiology & Biostatistics, Univ at Albany School of Public Health, Rensselaer; Wadsworth Center, New York State Dept of Health, Albany, NY; Dept of Pediatrics & Communicable Diseases, The Univ of Michigan Medical School, Ann Arbor, MI; Commisariat a l’energie Atomique (CEA), Institut Genomique, Centre National de Genotypage, Evry; Fondation Jean Dausset, Centre d’Etude du Polymorphisme Humain, Paris, France; Dept of Cardiovascular Medicine, Oxford University, Oxford; Inst of Genetics, Nottingham University, Nottingham; East Midlands Congenital Heart Centre, University Hospitals of Leicester NHS Trust, Leicester; Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne; Bristol Royal Hospital for Children, Bristol, United Kingdom; The Children’s Hospital at Westmead, Westmead, Australia; Academic Medical Center, Amsterdam, The Netherlands; Inst of Medical Genetics, University of Zurich, Switzerland; Pediatric Cardiology, Center for Human Genetics, Univ of Leuven, Leuven, Belgium; Institute of Cardiovascular Sciences, The Univ of Manchester, Manchester, UK † Present address: Illumina Inc. San Diego, CA