Synthesis of Fluorescence-Labelled Glycosidic Prodrugs Based on the Cytotoxic Antibiotic Duocarmycin (Eur. J. Org. Chem. 36/2010)

The cover picture shows live-cell images of novel fluorescence-labelled Duocarmycin analogues. Images a and b represent the cellular uptake of the new compound at λexc = 405 nm and λem = 500 nm (a) and at λexc = 514 nm and λem = 560 nm (b), whereas image c shows the overlap of a and b. Images d and f show colocalisation experiments with Hoechst 33342 (d) and MitoTracker® DeepRed (f), whereas image e shows the cellular uptake of the new compound (λexc = 514 nm, λem = 560 nm) again for comparison with MitoTracker® DeepRed. Details are discussed in the article by L. F. Tietze et al. on p. 6909 ff.