α-1-Acid glycoprotein as a biomarker for the early diagnosis and monitoring the prognosis of sepsis ☆ ☆☆

Abstract Objective To explore the value of α-1-acid glycoprotein (AGP) for the early diagnostic and prognostic assessment of patients with sepsis. Methods Eighty-five patients with systemic inflammatory response syndrome (SIRS) and 192 patients with sepsis were enrolled. White blood cell counts and serum levels of AGP, C-reactive protein, and procalcitonin were tested on the day of admission to intensive care unit (ICU; day 1) and the following days 3, 5, 7, and 10. Results The sepsis group exhibited significantly higher levels of AGP than did the SIRS group on day 1 ( P Conclusions α-1-Acid glycoprotein could distinguish sepsis from SIRS and also be used to effectively assess the severity of sepsis. In addition, combined AGP and SOFA scores had a great predicting value in prognosis of sepsis.